Huong Sen Hotel stands on Dong Khoi street, one of the best-known streets of District 1, lined with shops, hotels and colonial-era buildings. The Saigon Opera House, a French colonial theatre, is 200 m away, Me Linh Square is 250 m away and Ho Chi Minh City Hall is 400 m away. Ben Thanh Market, a covered market known for textiles, coffee and street food, Notre Dame Church and the General Post Office are all within 800 m of the hotel, so the market and the churches are a short walk from the door.
The nearest metro station is Opera House Station, 300 m away on Metro Line 1, and the Bến Bạch Đằng ferry terminal is 350 m away on the riverbank. Saigon Railway Station is about 3 km from the hotel, a short ride by taxi or ride-hailing car. Tan Son Nhat International Airport can be reached on the hotel's airport shuttle.
Walking routes from the hotel reach the Fine Arts Museum and Nha Rong Wharf, both 800 m away. Nha Rong Wharf is where Ho Chi Minh left Vietnam in 1911, and the Museum of Ho Chi Minh City, 500 m away, covers the city's history. Tao Dan Park, 1.3 km away, is a large green space with lawns and paths for a break between visits, and the War Remnants Museum, 1.4 km away, documents the Vietnam War with aircraft displayed outside. The Nguyen Hue walking street lies in the same district for an evening stroll.